Indoxacarb CAS NO.144171-61-9

Indacarb (trade name: ammate (home run, 30% water dispersible granule), avatar ~ (anda, L5% suspension), avant @ (sold on fruit trees and vegetables), steward ~ (sold on cotton) is a typical representative of oxadiazine insecticides, and also the first commercial (racemic insecticide initially listed, newly listed as a rich group) of sodium channel blocking insecticides The chemical name of the agent is s-7-chloro-2,5-dihydro-2 - [[(methoxycarbonyl) [4 - (Trifluoromethoxy) - phenyl] amino] carbonyl] Indeno [1,2-e] [1,3,4] oxadiazine-4 (3H) - carboxylic acid methyl ester. Although studies have shown that ninhydrin has a unique mechanism of action, which is different from any other insecticides, from a biological point of view, insect resistance to insecticides is a stress evolution phenomenon, which is accompanied by the selection of insecticides to insects. Any new insecticide, including ninhydrin, has the possibility of resistance. Ninhydrin is the first commercial oxadiazine insecticide. Laboratory bioassay and field efficacy test showed that ninhydrin had excellent insecticidal activity against almost all important agricultural Lepidoptera pests, such as cotton bollworm, tobacco bud night chemical Book moth, Plutella xylostella, cabbage worm, beet armyworm, pink armyworm, blue armyworm, apple moth, etc., and also against some Homoptera and coleoptera pests, such as leafhoppers, potato leafhoppers, peach aphids, potato beetles, etc It has a certain effect. In this paper, the metabolism of HC labelled indefencarb in Lepidoptera was studied by high performance liquid chromatography and mass spectrometry. It was found that indefencarb can be rapidly transformed into n-demethoxycarbonyl metabolite (DCJW) by Lepidoptera, which mainly occurs in the midgut and fat body, and can be inhibited by esterase inhibitor to oxygen phosphorus and defoliation phosphorus (DEF). It is speculated that the related catalytic enzyme may be An esterase. Further studies showed that the transformation of ninhydrin was different among different insects. Compared with non Lepidoptera, most Lepidoptera larvae were able to convert 90 ninhydrin into DCJW within 4 hours after administration. Compared with ninhydrin, DCJW was more effective in blocking the action potential of abdominal motor neurons of Spodoptera tabacum larvae, suggesting that ninhydrin was different The activation metabolic rate in insects is related to insecticidal activity and selectivity, which is also the reason why ninhydrin is low toxic to mammals and other non target organisms.